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產(chǎn)品規(guī)格
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BN40411R-100ul
100ul
￥2360.00
交叉反應：Human,Mouse,Rat(predicted:Dog,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN40411R-200ul
200ul
￥3490.00
交叉反應：Human,Mouse,Rat(predicted:Dog,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
產(chǎn)品描述
| 英文名稱 | FCGBP |
| 中文名稱 | Fcγ免疫球蛋白IgG結(jié)合蛋白抗體 |
| 別 名 | Fc fragment of IgG binding protein; FC(GAMMA)BP; Fcgamma-binding protein antigen; FcgammaBP; FCGBP; FCGBP_HUMAN; Human Fc gamma BP; IgGFc-binding protein. |
| 研究領域 | 細胞生物 免疫學 細胞膜受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, Rat, (predicted: Dog, Rabbit, ) |
| 產(chǎn)品應用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 569kDa |
| 細胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FCGBP:431-530/5405 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Fc (Ig constant fragment) receptors ensure protection of the host against foreign antigens, such as microorganisms and pathogens, by removing Ig-coated antigen complexes from circulation. Fc receptors are present on lymphoid and myeloid derivatives, where they mediate endocytosis of Ig-antigen complexes, antibody production in B cells through T cell antigen presentation, cytotoxicity and the release of cytokines and reactive oxygen species. The Fc γ-binding protein (FCGBP) interacts with the Fc portion of IgG and MUC2 to mediate the maintenance of the mucosal structure. FCGBP is a 5,405 amino acid protein that contains twelve TIL (trypsin inhibitory-like) domains and thirteen VWFD domains. It is predominantly expressed in placenta and colon epithelium as well as in thyroid and serum. Patients with various autoimmune diseases seemingly have higher levels of FCGBP protein present in their serum. Function: May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa. Subunit: Interacts with the Fc portion of IgG and with MUC2. Subcellular Location: Secreted. Tissue Specificity: Mainly expressed in placenta and colon epithelium. Expressed in thyroid, and down-regulated in thyroid carcinomas. Present in serum, with higher levels in patients with various autoimmune diseases (at protein level). Similarity: Contains 12 TIL (trypsin inhibitory-like) domains. Contains 13 VWFD domains. SWISS: Q9Y6R7 Gene ID: 8857 Database links: Entrez Gene: 8857 Human SwissProt: Q9Y6R7 Human Unigene: 111732 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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